Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

This PDF book is become immediate popular in Science genre. Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells is written by famous author Sandro Matosevic and Ready to Download in ePUB, PDF or Kindle formats. Released by Academic Press in 2021-01-29. Click Download Book button to get book file and read directly from your devices. Here is a quick description and cover image of Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells book.

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
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Publisher : Academic Press
Release Date :
ISBN : 0128206276
Pages : 200 pages
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Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells by Sandro Matosevic Book PDF Summary

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included. The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic. Discusses translational aspects from leaders in the field to facilitate readers' understanding of clinical challenges Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites


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